Publications

 
  1. Bach, A., C. Conzen, G. A. Schubert, C. Bleilevens, and U. Lindauer. 2019. Acute changes of pro-inflammatory markers and corticosterone in experimental subarachnoid haemorrhage: A prerequisite for severity assessment. PLoS One 14: e0220467.
  2. Beller, E., L. Reuter, A. Kluge, C. Preibisch, U. Lindauer, A. Bogdanov, F. Lammer, C. Delbridge, K. Matiasek, B. J. Schwaiger, T. Boeckh-Behrens, C. Zimmer, and A. S. Gersing. 2018. Pilot study to assess visualization and therapy of inflammatory mechanisms after vessel reopening in a mouse stroke model. Scientific reports 8: 745.
  3. Bethell, E. J., L. C. Cassidy, R. R. Brockhausen, and D. Pfefferle. 2019. Toward a Standardized Test of Fearful Temperament in Primates: A Sensitive Alternative to the Human Intruder Task for Laboratory-Housed Rhesus Macaques (Macaca mulatta). Frontiers in psychology 10: 1051.
  4. Bleich, A., and R. H. Tolba. 2017. How can we assess their suffering? German research consortium aims at defining a severity assessment framework for laboratory animals. Lab Anim 51: 667.
  5. Conzen, C., K. Becker, W. Albanna, M. Weiss, A. Bach, N. Lushina, A. Steimers, S. Pinkernell, H. Clusmann, U. Lindauer, and G. A. Schubert. 2018. The Acute Phase of Experimental Subarachnoid Hemorrhage: Intracranial Pressure Dynamics and Their Effect on Cerebral Blood Flow and Autoregulation. Translational stroke research 10: 566.
  6. Di Liberto, V., R. M. van Dijk, M. Brendel, A. M. Waldron, C. Moller, I. Koska, I. Seiffert, F. Gualtieri, F. J. Gildehaus, B. von Ungern-Sternberg, M. Lindner, S. Ziegler, R. Palme, R. Hellweg, P. Gass, P. Bartenstein, and H. Potschka. 2018. Imaging correlates of behavioral impairments: An experimental PET study in the rat pilocarpine epilepsy model. Neurobiol Dis 118: 9-21.
  7. Evangelista-Vaz, R., A. Bergadano, M. Arras, and P. D. Jirkof. 2018. Analgesic Efficacy of Subcutaneous-Oral Dosage of Tramadol after Surgery in C57BL/6J Mice. J Am Assoc Lab Anim Sci 57: 368-375.
  8. Hagemeister, K., L. Ernst, P. Kadaba Srinivasan, H. Tanaka, K. Fukushima, and R. Tolba. 2019. Severity assessment in pigs after partial liver resection: evaluation of a score sheet. Lab Anim: doi: 10.1177/0023677219871585.
  9. Häger, C., S. Biernot, M. Buettner, S. Glage, L. M. Keubler, N. Held, E. M. Bleich, K. Otto, C. W. Muller, S. Decker, S. R. Talbot, and A. Bleich. 2017. The Sheep Grimace Scale as an indicator of post-operative distress and pain in laboratory sheep. PLoS One 12: e0175839.
  10. Häger, C., L. M. Keubler, S. R. Talbot, S. Biernot, N. Weegh, S. Buchheister, M. Buettner, S. Glage, and A. Bleich. 2018. Running in the wheel: Defining individual severity levels in mice. PLoS Biol 16: e2006159.
  11. Hovel, F. F. V., I. Leiter, R. Rumpel, A. Langenhagen, D. Wedekind, C. Hager, A. Bleich, R. Palme, and C. Grothe. 2019. FGF-2 isoforms influence the development of dopaminergic neurons in the murine substantia nigra, but not anxiety-like behavior, stress susceptibility, or locomotor behavior. Behav Brain Res 374: 112113.
  12. Jirkof, P., M. Durst, R. Klopfleisch, R. Palme, C. Thone-Reineke, F. Buttgereit, K. Schmidt-Bleek, and A. Lang. 2019. Administration of Tramadol or Buprenorphine via the drinking water for post-operative analgesia in a mouse-osteotomy model. Scientific reports 9: 10749.
  13. Jirkof, P., and P. Seebeck. 2019. Vital signs without handling or animal prep. Lab Anim (NY) 48: 144-145.
  14. Keubler, L. M., R. H. Tolba, A. Bleich, and C. Häger. 2018. Severity assessment in laboratory animals: a short overview on potentially applicable parameters. Berl Münch Tierärztl Wochenschr 131: 299-303.
  15. Kopaczka, M., L. Ernst, J. Heckelmann, C. Schorn, R. Tolba, and D. Merhof. 2018. Automatic Key Frame Extraction From Videos For Efficient Mouse Pain Scoring. 2018 5th International Conference on Signal Processing and Integrated Networks (SPIN). IEEE: 248-252.
  16. Kopaczka, M., L. Ernst, J. Schock, A. Schneuing, A. Guth, R. Tolba, and D. Merhof. 2018. Introducing CNN-Based Mouse Grim Scale Analysis for Fully Automated Image-Based Assessment of Distress in Laboratory Mice. Proceedings of the Eurographics Workshop on Visual Computing for Biology and Medicine: 101-106.
  17. Kopaczka, M., D. T., L. Ernst, J. Schock, R. H. Tolba, and D. Merhof. Assessment of Laboratory Mouse Activity in Video Recordings Using Deep Learning Methods. International Engineering in Medicine and Biology Conference (EMBC).
  18. Koska, I., R. M. van Dijk, I. Seiffert, V. Di Liberto, C. Moller, R. Palme, R. Hellweg, and H. Potschka. 2019. Toward evidence-based severity assessment in rat models with repeated seizures: II. Chemical post-status epilepticus model. Epilepsia. ;60:2114–2127.
  19. Kumstel, S., G. Tang, X. Zhang, H. Kerndl, B. Vollmar, and D. Zechner. 2019. Grading Distress of Different Animal Models for Gastrointestinal Diseases Based on Plasma Corticosterone Kinetics. Animals (Basel) 9(4):145.
  20. Kunczik, J., C.B. Pereira, L. Zieglowski, R. Tolba, L. Wassermann, C. Häger, A. Bleich, H. Janssen , T. Thum, and M. Czaplik. 2019. Remote Vitals Monitoring in Rodents Using Video Recordings. Biomed. Opt. Express 10: 4422-4436.
  21. Kunczik, J., C. B. Pereira, L. Wassermann, C. Häger, A. Bleich, L. Zieglowski, R. Tolba, and M. Czaplik. 2019. Contactless anesthesia monitoring in spontaneously breathing rodents. International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).
  22. Mallien, A. S., S. T. Soukup, N. Pfeiffer, C. Brandwein, S. E. Kulling, S. Chourbaji, and P. Gass. 2019. Effects of Soy in Laboratory Rodent Diets on the Basal, Affective, and Cognitive Behavior of C57BL/6 Mice. J Am Assoc Lab Anim Sci.
  23. Mertens, S., M. A. Vogt, P. Gass, R. Palme, B. Hiebl, and S. Chourbaji. 2019. Effect of three different forms of handling on the variation of aggression-associated parameters in individually and group-housed male C57BL/6NCrl mice. PLoS One 14: e0215367.
  24. Möller, C., R. M. van Dijk, F. Wolf, M. Keck, K. Schonhoff, V. Bierling, and H. Potschka. 2019. Impact of repeated kindled seizures on heart rate rhythms, heart rate variability, and locomotor activity in rats. Epilepsy Behav 92: 36-44.
  25. Möller, C., F. Wolf, R. M. van Dijk, V. Di Liberto, V. Russmann, M. Keck, R. Palme, R. Hellweg, P. Gass, C. Otzdorff, and H. Potschka. 2018. Toward evidence-based severity assessment in rat models with repeated seizures: I. Electrical kindling. Epilepsia 59: 765-777.
  26. Pereira, C., J. Kunczik, A. Bleich, C. Haeger, F. Kiessling, T. Thum, R. Tolba, U. Lindauer, S. Treue, and M. Czaplik. 2019. Perspective review of optical imaging in welfare assessment in animal-based research. Journal of biomedical optics 24: 1-11.
  27. Pereira, C. B., J. Kunczik, L. Zieglowski, R. Tolba, A. Abdelrahman, D. Zechner, B. Vollmar, H. Janssen, T. Thum, and M. Czaplik. 2018. Remote Welfare Monitoring of Rodents Using Thermal Imaging. Sensors (Basel) 18(11). pii: E3653.
  28. Pfefferle, D., S. Plumer, L. Burchardt, S. Treue, and A. Gail. 2018. Assessment of stress responses in rhesus macaques (Macaca mulatta) to daily routine procedures in system neuroscience based on salivary cortisol concentrations. PLoS One 13: e0190190.
  29. Rix, A., N. I. Drude, A. Mrugalla, F. Baskaya, K. Y. Pak, B. Gray, H. J. Kaiser, R. H. Tolba, E. Fiegle, W. Lederle, F. M. Mottaghy, and F. Kiessling. 2019. Assessment of Chemotherapy-Induced Organ Damage with Ga-68 Labeled Duramycin. Mol Imaging Biol.
  30. Schmidt, M., F. Lapert, C. Brandwein, M. Deuschle, C. Kasperk, J. M. Grimsley, and P. Gass. 2017. Prenatal stress changes courtship vocalizations and bone mineral density in mice. Psychoneuroendocrinology 75: 203-212.
  31. Schwabe, K., L. Boldt, A. Bleich, R. M. van Dijk, S. O. A. Helgers, C. Hager, M. Nowakowska, A. K. Riedesel, K. Schonhoff, B. Struve, J. Wittek, and H. Potschka. 2019. Nest-building performance in rats: impact of vendor, experience, and sex. Lab Anim: 23677219862004.
  32. Seiffert, I., R. M. van Dijk, I. Koska, V. Di Liberto, C. Moller, R. Palme, R. Hellweg, and H. Potschka. 2019. Toward evidence-based severity assessment in rat models with repeated seizures: III. Electrical post-status epilepticus model. Epilepsia 60: 1539-1551.
  33. Talbot, S. R., S. Bruch, F. Kiessling, M. Marschollek, B. Jandric, R. H. Tolba, and A. Bleich. 2019. Design of a joint research data platform: A use case for severity assessment. Lab Anim: 23677219872228.
  34. Tihanyi, D. K., A. Szijarto, A. Fulop, B. Denecke, G. Lurje, U. P. Neumann, Z. Czigany, and R. Tolba. 2019. Systematic Review on Characteristics and Reporting Quality of Animal Studies in Liver Regeneration Triggered by Portal Vein Occlusion and Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy: Adherence to the ARRIVE Guidelines. J Surg Res 235: 578-590.
  35. Unakafov, A. M., S. Moller, I. Kagan, A. Gail, S. Treue, and F. Wolf. 2018. Using imaging photoplethysmography for heart rate estimation in non-human primates. PLoS One 13: e0202581.
  36. Van der Mierden, S., K. Tsaioun, A. Bleich, and C. H. C. Leenaars. 2019. Software tools for literature screening in systematic reviews in biomedical research. ALTEX 36: 508-517.
  37. van Dijk, R. M., V. Di Liberto, M. Brendel, A. M. Waldron, C. Moller, F. J. Gildehaus, B. von Ungern-Sternberg, M. Lindner, S. Ziegler, R. Hellweg, P. Gass, P. Bartenstein, and H. Potschka. 2018. Imaging biomarkers of behavioral impairments: A pilot micro-positron emission tomographic study in a rat electrical post-status epilepticus model. Epilepsia 59: 2194-2205.
  38. Venugopal, K., S. N. Unni, A. Bach, C. Conzen, and U. Lindauer. 2019. Assessment of cerebral hemodynamics during neurosurgical procedures using laser speckle image analysis. J Biophotonics 12: e201800408.

Accepted Publications (in press)

  1. Abdelrahman, A., S. Kumstel, X. Zhang, M. Liebig, E. H. U. Wendt, J. Eichberg, R. Palme, T. Thum, B. Vollmar, and D. Zechner. A novel multi-parametric analysis of non-invasive methods to assess animal distress during chronic pancreatitis. Scientific reports. Ernst, L., M. Kopaczka, M. Schulz, S. R. Talbot, B. Struve, C. Häger, A. Bleich, M. Durst, P. Jirkof, M. Arras, R. M. v. Dijk, N. Miljanovic, H. Potschka, D. Merhof, and R. H. Tolba. Semi-automated generation of pictures for the Mouse Grimace Scale: a multilab analysis (Part II). Lab Anim.
  2. Ernst, L., M. Kopaczka, M. Schulz, S. R. Talbot, L. Zieglowski, M. Meyer, S. Bruch, D. Merhof, and R. H. Tolba. Improvement of the Mouse Grimace Scale Set-up for Implementing a Semi-automated Mouse Grimace Scale Scoring (Part I). Lab Anim.
  3. Jirkof, P., A. Abdelrahman, A. Bleich, M. Durst, L. Keubler, H. Potschka, B. Struve, S. Talbot, B. Vollmar, D. Zechner, and C. Häger. A safe bet? Inter-laboratory variability in behavior-based severity assessment. Lab Anim.
  4. Keubler, L. M., N. Hoppe, H. Potschka, S. R. Talbot, B. Vollmar, D. Zechner, C. Häger, and A. Bleich. Where are we heading? Challenges in evidence-based severity assessment. Lab Anim.
  5. Kumstel, S., P. Vasudevan, R. Palme, X. Zhang, E. H. U. Wendt, R. David, B. Vollmar, and D. Zechner. Benefits of non-invasive methods for distress analysis in comparison to telemetry. J. Adv. Res.
  6. Leenaars, C. H. C., S. v. d. Mierden, M. Durst, V. Goerlich-Jansson, F. L. Ripoli, L. Keubler, S. Talbot, E. Boyle, A. Habedank, P. Jirkof, L. Lewejohann, P. Gass, R. Tolba, and A. Bleich. Measurement of corticosterone in mice: a protocol for a mapping review. Lab Anim.
  7. Mallien, A. S., C. Häger, R. Palme, S. R. Talbot, M. A. Vogt, N. Pfeiffer, C. Brandwein, B. Struve, D. Inta, S. Chourbaji, R. Hellweg, B. Vollmar, A. Bleich, and P. Gass. Systematic analysis of severity in a widely-used cognitive depression model for mice. Lab Anim.
  8. Rix, A., N. I. Drude, A. Mrugralla, F. M. Mottaghy, R. H. Tolba, and F. Kiessling. Performance of severity parameters to detect chemotherapy induced pain and distress in mice. Lab Anim.
  9. Talbot, S. R., S. Biernot, A. Bleich, R. M. van Dijk, L. Ernst, C. Häger, S. O. A. Helgers, B. Koegel, I. Koska, A. Kuhla, N. Miljanovic, F. T. Müller-Graff, K. Schwabe, R. H. Tolba, B. Vollmar, N. Weegh, T. Wölk, F. Wolf, A. Wree, L. Zieglowski, H. Potschka, and D. Zechner. Defining body weight reduction as a humane endpoint: a critical appraisal. Lab Anim. HP and DZ equal contribution/shared last authorship.
  10. Weegh, N., J. Füner, O. Jahnke, Y. Winter, C. Jung, B. Struve, L. Wassermann, L. Lewejohann, A. Bleich, and C. Häger. Wheel running behaviour in group-housed female mice indicates disturbed wellbeing due to DSS colitis. Lab Anim.